I like lighter skin textures and use DNA in SimPE to change Sims that I want to change. In a new disc installation on Windows 10...but don't think it has anything to do with Windows 10, I was changing some DNA's of original Sims in Pleasantview. Had a problem with Ramierez, Landgraab IV and Tinker families, but no problem with others in same sub hood. Just occurred to me that I did modify facial structure using Mirror, prior to trying to change DNA. Could this be the cause and if so is there anything I can do to change the DNA. It won't open at all currently...neither will Family ???